The difference would be the increase in the initial outlay. For example (hope this is the same type of question you are looking at):
Y0 -10000
Y1 20000
Y2 20000
NPV = -10000+20000/(1+r)+20000/(1+r)^2
If now the initial outlay is -15000 instead of -10000,
NPV = -15000+20000/(1+r)+20000/(1+r)^2
Then take the 1st equation subtract the 2nd, gives you 5000 difference. This would be significantly faster.
If they asked to compare NPV of 2 projects with difference cash flows, just simply find the NPV of the difference in cashflow. If the result is +, then NPVa > NPVb, otherwise NPVa < NPVb. However, I think it would just 10-15s faster than the usual method.